Tirzepatide in Singapore: Uses, Benefits, Side Effects & What You Should Know

What Is Tirzepatide?

Tirzepatide is a once-weekly injectable medication that mimics two gut hormones — GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 (glucagon-like peptide-1). By activating both pathways, it helps regulate appetite, improve insulin sensitivity, delay gastric emptying, and enhance satiety.

Originally developed for type 2 diabetes management, tirzepatide has gained global attention for its potent weight-loss effects, often outperforming other weight-loss injectables like semaglutide in clinical studies.

In Singapore, tirzepatide is prescription-only and must be initiated after a medical evaluation.

How Does Tirzepatide Work?

Tirzepatide targets two insulin-regulating hormones:

• GLP-1: slows gastric emptying, increases fullness after meals, and boosts insulin release

• GIP: further enhances insulin response and may contribute to greater weight loss

This dual-action mechanism is why tirzepatide often delivers stronger results than single-pathway drugs.

Benefits of Tirzepatide

1. Improved Blood Sugar Control

For individuals with type 2 diabetes, tirzepatide helps lower HbA1c and stabilise glucose levels — serving as an adjunct to diet and exercise.

2. Effective Weight Loss

Clinical evidence suggests tirzepatide can lead to greater average weight loss compared to older GLP-1 therapies, making it a compelling option for medically supervised weight management.

3. Appetite Regulation

Patients often report decreased hunger and reduced caloric intake as a key driver of weight loss.

4. Metabolic Benefits

By improving insulin sensitivity and glucose control, tirzepatide may indirectly support cardiovascular and metabolic health when combined with lifestyle modifications.

Who Is Tirzepatide Suitable For?

Tirzepatide may be considered for adults with:

• Type 2 diabetes requiring better glycaemic control

• Obesity or overweight with weight-related health issues

• Individuals struggling with weight loss despite lifestyle changes

A consultation with a clinician is critical to assess eligibility and tailor dosing.

Potential Side Effects

Like all medications, tirzepatide may cause side effects — mostly mild to moderate and often transient:

• Nausea
• Diarrhoea or constipation
• Reduced appetite
• Mild abdominal discomfort

Most side effects occur during dose escalation and improve over time with proper medical supervision.

What to Expect During Treatment

A typical tirzepatide plan involves:

1. Initial medical consultation

2. Prescription and education on injection technique

3. Weekly subcutaneous injections

4. Regular monitoring of blood glucose, weight & vitals

This structured approach maximises safety and outcomes.

Tirzepatide vs. Other Weight-Loss Injectables

Tirzepatide works on two hormone pathways (GIP and GLP-1), while some other commonly used injectables act on a single pathway. Because of this difference, doctors may consider tirzepatide as one of several possible medical options in weight and metabolic management.

The choice between different injectables depends on factors such as individual health profile, treatment goals, response, and medical suitability, and should always be determined through a doctor’s consultation.

Take Charge of Your Metabolic Health Today

Your metabolic health plays an important role in your energy levels, weight regulation, and long-term wellbeing. Concerns around blood sugar control or weight can affect daily life if left unaddressed.

With medical guidance at Healthsprings Medical Clinic, tirzepatide may be considered as part of a structured, doctor-led approach to metabolic and weight management, together with lifestyle support.

Learn more about tirzepatide treatment in Singapore and whether it may be suitable for you by speaking with our medical team below.